Document Detail


Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for diabetic retinopathy in Japanese patients with type 2 diabetes.
MedLine Citation:
PMID:  20488574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the association between diabetic retinopathy and monocyte chemoattractant protein (MCP)-1 A-2518G polymorphism in 3802 Japanese type 2 diabetic subjects. The prevalence of diabetic retinopathy was higher as the number of G alleles increased, suggesting that the G allele of this polymorphism is a susceptibility allele for diabetic retinopathy.
Authors:
Naoto Katakami; Munehide Matsuhisa; Hideaki Kaneto; Taka-aki Matsuoka; Kenichi Imamura; Fukashi Ishibashi; Tsutomu Kanda; Koichi Kawai; Takeshi Osonoi; Atsunori Kashiwagi; Ryuzo Kawamori; Iichiro Shimomura; Yoshimitsu Yamasaki
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Publication Detail:
Type:  Journal Article     Date:  2010-05-21
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  89     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  e9-12     Citation Subset:  IM    
Affiliation:
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. katakami@medone.med.osaka-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Asian Continental Ancestry Group / genetics*,  statistics & numerical data
Chemokine CCL2 / genetics*
Diabetes Mellitus, Type 2 / ethnology*,  genetics*
Diabetic Retinopathy / ethnology*,  genetics*
Female
Genetic Predisposition to Disease / ethnology
Genotype
Humans
Japan / epidemiology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Pneumococcal Vaccines
Polymorphism, Genetic
Risk Factors
Chemical
Reg. No./Substance:
0/CCL2 protein, human; 0/Chemokine CCL2; 0/Pneumococcal Vaccines; 0/heptavalent pneumococcal conjugate vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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