Document Detail

Monocyte bone degradation: in vitro analysis of monocyte activity in patients with juvenile rheumatoid arthritis.
MedLine Citation:
PMID:  3081699     Owner:  NLM     Status:  MEDLINE    
We examined the ability of the mononuclear phagocyte in vitro to degrade 45Ca-labeled bone particles to determine whether this assay allowed us to monitor disease activity in patients with juvenile rheumatoid arthritis. The monocytes from patients with juvenile rheumatoid arthritis receiving no anti-erosive therapy (n = 10) degraded significantly more bone than did cells obtained from normal controls (n = 10, P less than 0.001) or patients with juvenile rheumatoid arthritis receiving either gold thioglucose (n = 4, P less than 0.001) or D-penicillamine (n = 6, P less than 0.005). In two patients monitored for either 8 or 11 months, results of monocyte assays were found to parallel the clinical course. We conclude that in vitro monocyte bone degradation assays may provide a means of assessing joint activity in patients with juvenile rheumatoid arthritis. Further, this study and others indicate that mononuclear phagocytes are capable of causing erosive changes.
L L Key; S Hoch; L Cairns; D Carnes; E Beyer; C S Anast
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Publication Detail:
Type:  Case Reports; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  108     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-02     Completed Date:  1986-04-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-9     Citation Subset:  AIM; IM    
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MeSH Terms
Arthritis, Juvenile Rheumatoid / blood*,  drug therapy
Aurothioglucose / therapeutic use
Bone and Bones / pathology*
Calcium Radioisotopes / diagnostic use
Child, Preschool
Infant, Newborn
Leukocyte Count
Monocytes / physiology*
Penicillamine / therapeutic use
Grant Support
Reg. No./Substance:
0/Calcium Radioisotopes; 12192-57-3/Aurothioglucose; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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