| Monocyte Differentiation toward Regulatory Dendritic Cells Is Not Affected by Respiratory Syncytial Virus-Induced Inflammatory Mediators. | |
| | |
MedLine Citation:
|
PMID: 20595462 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Airway epithelial cells were shown to drive the differentiation of monocytes into dendritic cells (DCs) with a suppressive phenotype. In this study, we investigated the impact of virus-induced inflammatory mediator production on the development of DCs. Monocyte differentiation into functional DCs, as reflected by the expression of CD11c, CD123, BDCA-4, and DC-SIGN and the capacity to activate T cells, was similar for respiratory syncytial virus (RSV)-infected and mock-infected BEAS-2B and A549 cells. RSV-conditioned culture media resulted in a partially mature DC phenotype, but failed to up-regulate CD80, CD83, CD86, and CCR7, and failed to release proinflammatory mediators upon Toll-like receptor (TLR) triggering. Nevertheless, these DCs were able to maintain an antiviral response by the release of Type I IFN. Collectively, these data indicate that the airway epithelium maintains an important suppressive DC phenotype under the inflammatory conditions induced by infection with RSV. |
| | |
Authors:
|
Koenraad F van der Sluijs; Carolina Obregon; Thomas K Geiser; Kathrin Mühlemann; Laurent P Nicod |
Publication Detail:
|
Type: Journal Article Date: 2010-07-01 |
Journal Detail:
|
Title: American journal of respiratory cell and molecular biology Volume: 44 ISSN: 1535-4989 ISO Abbreviation: Am. J. Respir. Cell Mol. Biol. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 655-64 Citation Subset: IM |
Affiliation:
|
P.O. Box 22700, 1100 DD Amsterdam, The Netherlands. kvandersluijs@amc.uva.nl. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolic alterations in organic acids and gamma-aminobutyric acid in developing tomato (Solanum lyc...
Next Document: Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatm...