| Monocyte Deactivation Correlates With Injury Severity Score, But Not With Heme Oxygenase-1 Levels in Trauma Patients. | |
| | |
MedLine Citation:
|
PMID: 21601878 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Traumatic injury induces a local and systemic release of pro-inflammatory cytokines, acute phase proteins, hormones, and other inflammatory mediators. The excessive release of these mediators plays an important role in the pathogenesis of shock. In parallel to this pro-inflammatory response, there is a regulatory response characterized by the release of anti-inflammatory mediators, which is thought to represent the host's attempt to restore immunological equilibrium. Studies in septic patients have suggested the compensatory anti-inflammatory response may result in an "immunodeficient state" that leaves the host susceptible to further infectious insults. A key feature of the anti-inflammatory state in septic patients is a change in the responsiveness of monocytes that has been termed "monocyte deactivation." This is supported by data that link monocyte deactivation to increased mortality in septic patients. Monocytes with reduced HLA-DR expression have been described in trauma patients. We collected blood from 25 severely injured patients and evaluated peripheral blood mononuclear cells (PBMC) for HLA-DR expression and TNF-α response to LPS stimulation as markers of monocyte deactivation. Levels of intracellular HO-1 were determined in each patient, as HO-1 has been implicated in monocyte deactivation in patients with severe systemic inflammatory response syndrome (SIRS). HLA-DR expression correlated inversely with Injury Severity Scores and TNF-α response to LPS stimulation, but failed to correlate with HO-1 levels in these patients. HLA-DR expression was decreased in normal monocytes stimulated with patient plasma, but this treatment had no effect on HO-1 levels. These results suggest monocyte deactivation in trauma patients is unlikely to be mediated by HO-1. |
| | |
Authors:
|
Sonlee D West; Carolyn Mold |
Related Documents
:
|
12653388 - A new look at the pathophysiology of asthma. 2693368 - Effects of monocyte- and macrophage-derived products on granulocyte function in asthma. 17130678 - Respiratory viral infections and early asthma in childhood. 10612578 - Mechanisms of bronchial hyperresponsiveness: the interaction of endothelin-1 and other ... 16950278 - Il-25 enhances allergic airway inflammation by amplifying a th2 cell-dependent pathway ... 22158628 - Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-5 |
Journal Detail:
|
Title: The Journal of surgical research Volume: - ISSN: 1095-8673 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, New Mexico. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Novel CT Volume Index Score Correlates with Outcomes in Polytrauma Patients with Pulmonary Contusi...
Next Document: Gene Pathway Analysis of Hepatocellular Carcinoma Genomic Expression Datasets.