| Monocyte angiotensin converting enzyme expression may be associated with atherosclerosis rather than arteriosclerosis in hemodialysis patients. | |
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MedLine Citation:
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PMID: 21127137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Circulating monocytes can be divided into functionally distinct subpopulations according to their surface expression of CD14 and CD16. Monocytes with high-level expression of both antigens (CD14(++)CD16(+), Mo2 cells) are associated with cardiovascular morbidity and mortality in hemodialysis patients. These cells express angiotensin converting enzyme (ACE) on their surface. They are involved in the association of chronic inflammation and cardiovascular disease in kidney patients. Cardiovascular morbidity results from atherosclerosis (plaque-forming, vessel occluding disease) and arteriosclerosis (loss of arterial dampening function). It is unknown whether ACE-expressing proinflammatory monocytes are related to atherosclerosis, arteriosclerosis, or both. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: During baseline examination for a prospective study on monocyte ACE expression and mortality, 60 chronic hemodialysis patients of an academic outpatient center were screened for atherosclerosis by carotid artery ultrasound, for arteriosclerosis by pulse pressure measurement, and for ACE expression on Mo2 cells by flow cytometry. RESULTS: ACE expression on Mo2 monocytes was significantly higher in patients with severe compared with those with little or no carotid atherosclerosis. Mo2 ACE correlated with a score to semiquantify atherosclerosis and remained a significant predictor of carotid plaques in multivariate analysis including the other univariately associated variables of age, hemoglobin A1c, and albumin. Mo2 ACE was not related to pulse pressure. CONCLUSIONS: ACE expression on Mo2, although being a known predictor of mortality and cardiovascular disease in end-stage renal disease patients, may act via enhancement of atherosclerosis rather than arteriosclerosis. |
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Authors:
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Christof Ulrich; Eric Seibert; Gunnar H Heine; Danilo Fliser; Matthias Girndt |
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Publication Detail:
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Type: Journal Article Date: 2010-12-02 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 6 ISSN: 1555-905X ISO Abbreviation: Clin J Am Soc Nephrol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-17 Completed Date: 2011-06-30 Revised Date: 2012-03-01 |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 505-11 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine II, Martin Luther University, Halle-Wittenberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Academic Medical Centers Adult Aged Aged, 80 and over Antigens, CD14 / blood Arteriosclerosis / diagnosis, enzymology, etiology*, physiopathology Atherosclerosis / enzymology, etiology*, ultrasonography Blood Pressure Carotid Artery Diseases / enzymology*, etiology, physiopathology, ultrasonography Female Flow Cytometry GPI-Linked Proteins / blood Germany Humans Kidney Failure, Chronic / complications, therapy* Linear Models Male Middle Aged Monocytes / enzymology*, immunology Peptidyl-Dipeptidase A / blood* Prospective Studies Pulsatile Flow Receptors, IgG / blood Renal Dialysis* / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD14; 0/FCGR3B protein, human; 0/GPI-Linked Proteins; 0/Receptors, IgG; EC 3.4.15.1/Peptidyl-Dipeptidase A |
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