Document Detail

Monoclonal gammopathy of undetermined significance evolving directly in primary plasma cell leukemia.
MedLine Citation:
PMID:  9309249     Owner:  NLM     Status:  MEDLINE    
A case of monoclonal gammopathy of undetermined significance (MGUS) which evolved directly into primary plasma cell leukemia (PCL) is reported. Even if MGUS and PCL represent the opposite aspects of the same immunoproliferative disorder, no previous cases of this direct evolution have been described, as stated by an accurate review of the specific literature. The patient abruptly developed PCL after five months from the discovery of a serum monoclonal spike, without any other clinical, laboratory and radiological abnormalities. The practical conclusions of this case report indicate that a patient with MGUS must be followed periodically and over an indefinite period, and that PCL must be considered into the possible evolution of MGUS.
P Pasqualetti; R Casale
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  51     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-21     Completed Date:  1997-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  284-5     Citation Subset:  IM    
Department of Internal Medicine and Public Health, School of Medicine and Surgery, University of L'Aquila, Italy.
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MeSH Terms
Leukemia, Plasma Cell / complications,  diagnosis*
Middle Aged
Paraproteinemias / etiology*

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