| Monoclonal gammopathies and malignancies in patients with chronic urticaria. | |
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MedLine Citation:
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PMID: 16961504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) has been described in association with chronic urticaria (CU) in patients with Schnitzler syndrome. Chronic urticaria may be a manifestation of hematologic malignancies. METHODS: This study was conducted to evaluate the frequency and characteristics of MGUS or malignancy in patients with CU. The Mayo Clinic electronic database was reviewed to identify patients with the diagnosis of CU. RESULTS: Of the 1639 patients presenting with CU between 1994 and 2001, 797 (49%) underwent laboratory evaluation for the presence of a coexisting monoclonal protein. Forty-seven CU patients had MGUS, 142 had a malignancy, and 24 had both. Fifteen percent of CU patients with MGUS had a hematologic malignancy compared with 0.9% of CU patients without MGUS (P < 0.001). Patients presenting with a new diagnosis of CU at an older age (> 56 years) were more likely to have associated underlying MGUS. The occurrence of MGUS in this group was higher than the reported incidence of MGUS in the general population. CONCLUSIONS: Patients with CU younger than 43 years were unlikely to have associated MGUS or malignancy. A higher percentage of patients with CU and MGUS had an associated diagnosis of hematologic malignancy. |
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Authors:
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Martha Karakelides; Kristi L Monson; Gerald W Volcheck; Catherine R Weiler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 45 ISSN: 0011-9059 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-11 Completed Date: 2006-10-19 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1032-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Division of Allergic Diseases, Mayo Clinic, Rochester, MN 55905, USA. weiler.catherine@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Age Factors Aged Blood Proteins / metabolism Chronic Disease Complement C4 / metabolism Female Humans Immunoglobulin A / blood Immunoglobulin G / blood Immunoglobulin M / blood Male Middle Aged Neoplasms / complications* Paraproteinemias / blood, complications* Thyrotropin / blood Urticaria / blood, complications*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Complement C4; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 9002-71-5/Thyrotropin |
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