Document Detail


Monoclonal antibodies with specificity for hairy cell leukemia cells.
MedLine Citation:
PMID:  7047565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hairy cell leukemia is a well described clinical entity, but the cell of origin for this leukemic cell and its function are still unknown. There are no totally specific markers for this cell, although tartrate-resistant acid phosphatase staining has been used extensively as a diagnostic test. This study describes three monoclonal murine antibodies with variable specificity for hairy cells. Antibody 1 was highly specific for hairy cells and was not found to react with normal or leukemic cells in this limited study. It did not react with the cells of all patients. It also did not react with all of the hairy cells of some of the positive cases. Antibodies 2 and 3 reacted with virtually all hairy cells but not with normal peripheral blood cells. However, reactions were obtained with certain leukemic myelomonoblasts and some activated B cells. The most obvious use for these three antibodies is for diagnostic purposes. They should also be helpful reagents to investigate the origin of the leukemic hairy cell. The possibility that antibody 1 detects a tumor-specific antigen is discussed.
Authors:
D N Posnett; N Chiorazzi; H G Kunkel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  70     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  254-61     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / immunology*
Antibody Specificity
B-Lymphocytes / immunology
Fluorescent Antibody Technique
Humans
Leukemia, Hairy Cell / diagnosis,  immunology*
Monocytes / immunology
Splenectomy
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal
Comments/Corrections

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