Document Detail


Monoclonal antibodies for asthma and chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  23282002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: In asthma and chronic obstructive pulmonary disease (COPD), the inflammation in the airways cannot always be controlled with conventional therapies, such as inhaled corticosteroids. Addition of more specific anti-inflammatory therapies, such as monoclonal antibodies, against inflammation pathways might improve the disease outcome.
AREAS COVERED: This review individually discusses the major inflammation pathways and their potential blocking monoclonal antibodies in asthma and COPD.
EXPERT OPINION: The current use of omalizumab in asthma provides a good example on the potential therapeutic role of monoclonal antibodies in both asthma and COPD. There are many other monoclonal antibodies which are currently investigated as possible therapies in these diseases. The identification of the disease subsets in which such antibodies might exert the maximum benefit opens the door for personalized medicine and for targeted biological therapy in asthma and COPD.
Authors:
Sabina Antonela Antoniu
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-03
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  13     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-06-19     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  257-68     Citation Subset:  IM    
Affiliation:
University of Medicine and Pharmacy, Pulmonary Disease University Hospital, Division of Pulmonary Disease, Iasi 700115, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / therapeutic use*
Asthma / drug therapy*,  immunology
Chemokines / immunology
Cytokines / immunology
Humans
Pulmonary Disease, Chronic Obstructive / drug therapy*,  immunology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Chemokines; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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