| Monoclonal antibodies for asthma and chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 23282002 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: In asthma and chronic obstructive pulmonary disease (COPD), the inflammation in the airways cannot always be controlled with conventional therapies, such as inhaled corticosteroids. Addition of more specific anti-inflammatory therapies, such as monoclonal antibodies, against inflammation pathways might improve the disease outcome. Areas covered: This review individually discusses the major inflammation pathways and their potential blocking monoclonal antibodies in asthma and COPD. Expert opinion: The current use of omalizumab in asthma provides a good example on the potential therapeutic role of monoclonal antibodies in both asthma and COPD. There are many other monoclonal antibodies which are currently investigated as possible therapies in these diseases. The identification of the disease subsets in which such antibodies might exert the maximum benefit opens the door for personalized medicine and for targeted biological therapy in asthma and COPD. |
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Authors:
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Sabina Antonela Antoniu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-3 |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: - ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Medicine and Pharmacy, Pulmonary Disease University Hospital, Division of Pulmonary Disease , Iasi 700115 , Romania sabina.antonela.antoniu@pneum.umfiasi.ro. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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