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Monoclonal anti-torpedo receptor antibodies used to study antibody heterogeneity in myasthenic sera.
MedLine Citation:
PMID:  20487854     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Monoclonal antibodies against Torpedo acetylcholine receptor were used to define the binding regions of cross-reacting, anti-receptor antibodies from sera of myasthenic patients. Cross-reacting antibodies were directed mainly against the toxin-binding region of the receptor and a region remote from the acetylcholine-binding site. Few patients had antibodies against the acetylcholine-binding site region. The monoclonal antibodies provide probes for defining the heterogeneity of anti-receptor antibodies in myasthenic sera.
Authors:
R W James; A K Lefvert; C Alliod; B W Fulpius
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurochemistry international     Volume:  4     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  1982  
Date Detail:
Created Date:  2010-05-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  -    
Affiliation:
Dept. of Biochemistry, University of Geneva, Geneva, Switzerland.
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