Document Detail


Monoclonal anti-TNF antibodies can elevate hemoglobin level in patients with ankylosing spondylitis.
MedLine Citation:
PMID:  23143665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Anti-TNF-alpha therapy with monoclonal antibodies (adalimumab and infliximab) did not only suppress disease activity but also provided a significant improvement in HGB levels. In the groups of treated with a TNF-alpha receptor antagonist (ETA) and non-biological agents, disease activity was suppressed, but there was not founded significant improvement in HGB levels after 52 weeks. Different outcomes of anti-TNF agents may be associated with their different effect mechanisms.
Authors:
Cemal Bes; Ayten Yazici; Mehmet Soy
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Publication Detail:
Type:  Journal Article     Date:  2012-11-13
Journal Detail:
Title:  Rheumatology international     Volume:  33     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-27     Completed Date:  2014-01-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1415-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal / therapeutic use*
Antibodies, Monoclonal, Humanized / therapeutic use
Antirheumatic Agents / therapeutic use*
Blood Sedimentation
C-Reactive Protein / analysis
Hemoglobins / analysis*
Humans
Immunoglobulin G / therapeutic use
Middle Aged
Receptors, Tumor Necrosis Factor / therapeutic use
Spondylitis, Ankylosing / blood,  drug therapy*
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antirheumatic Agents; 0/Hemoglobins; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 185243-69-0/TNFR-Fc fusion protein; 9007-41-4/C-Reactive Protein; FYS6T7F842/adalimumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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