Document Detail


Monoclonal B-cells in blood in non-Hodgkin lymphoma. Correlation with clinical features and prognoses.
MedLine Citation:
PMID:  2590539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Presence of monoclonal B-cells in peripheral blood (MBCB) was studied in 132 previously untreated patients with non-Hodgkin lymphoma classified according to the Kiel classification. Detection of B-cells was performed by immunofluorescence microscopy, using antibodies against immunoglobulin light chains. Thirty-six patients (27%) were found to have MBCB. In the subgroup of low grade lymphomas 25/75 (33%) and in high grade lymphomas, 11/57 (19%) had MBCB. Presence of MBCB was correlated to clinical stage and 81% of the patients with MBCB were in stage IV. Twenty-two out of 36 (61%) patients with MBCB had normal lymphocyte counts (less than 5.0 X 10(9]. MBCB indicated a less favourable prognosis, mainly due to the close association with stage IV. It was concluded that studies of MBCB by this simple method are useful in detecting 'subclinical' blood involvement and valuable in the initial staging procedure as well as in the follow-up of the patients.
Authors:
J Lindh; H Johansson; P Lenner; G Roos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  28     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-22     Completed Date:  1990-01-22     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  641-6     Citation Subset:  IM    
Affiliation:
Department of Oncology, University of Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols*
B-Lymphocytes / immunology*
Bone Marrow Diseases / etiology
Cyclophosphamide / therapeutic use
Doxorubicin / therapeutic use
Female
Humans
Leukocyte Count
Lymphoma, Non-Hodgkin / blood*,  drug therapy,  mortality
Male
Middle Aged
Prednisone / therapeutic use
Prognosis
Survival Rate
Vincristine / therapeutic use
Chemical
Reg. No./Substance:
0/CHOP protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine

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