Document Detail

Monoclonal B-cells in blood in non-Hodgkin lymphoma. Correlation with clinical features and prognoses.
MedLine Citation:
PMID:  2590539     Owner:  NLM     Status:  MEDLINE    
Presence of monoclonal B-cells in peripheral blood (MBCB) was studied in 132 previously untreated patients with non-Hodgkin lymphoma classified according to the Kiel classification. Detection of B-cells was performed by immunofluorescence microscopy, using antibodies against immunoglobulin light chains. Thirty-six patients (27%) were found to have MBCB. In the subgroup of low grade lymphomas 25/75 (33%) and in high grade lymphomas, 11/57 (19%) had MBCB. Presence of MBCB was correlated to clinical stage and 81% of the patients with MBCB were in stage IV. Twenty-two out of 36 (61%) patients with MBCB had normal lymphocyte counts (less than 5.0 X 10(9]. MBCB indicated a less favourable prognosis, mainly due to the close association with stage IV. It was concluded that studies of MBCB by this simple method are useful in detecting 'subclinical' blood involvement and valuable in the initial staging procedure as well as in the follow-up of the patients.
J Lindh; H Johansson; P Lenner; G Roos
Related Documents :
18333649 - A population-based evaluation of antenatal diagnosis of orofacial clefts.
18786959 - Retinopathy of prematurity in small-for-gestational age infants compared with those of ...
11335739 - Screening guidelines for retinopathy of prematurity: the need for revision in extremely...
10469809 - Current incidence of retinopathy of prematurity, 1989-1997.
20128569 - Retinopathy of prematurity in very low birth weight infants and the potential protectiv...
24666789 - Transient abdominal wall deformity in an infant blaming the caudal?
19555479 - Analysis of circulating hem-endothelial marker rna levels in preterm infants.
4077759 - Evaluation of crossbred brahman and continental european beef cattle in a subtropical e...
10099519 - Decolorization of molasses and a dye by a newly isolated strain of the fungus geotrichu...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  28     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-22     Completed Date:  1990-01-22     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  641-6     Citation Subset:  IM    
Department of Oncology, University of Umeå, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Combined Chemotherapy Protocols*
B-Lymphocytes / immunology*
Bone Marrow Diseases / etiology
Cyclophosphamide / therapeutic use
Doxorubicin / therapeutic use
Leukocyte Count
Lymphoma, Non-Hodgkin / blood*,  drug therapy,  mortality
Middle Aged
Prednisone / therapeutic use
Survival Rate
Vincristine / therapeutic use
Reg. No./Substance:
0/CHOP protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Smoking and passive smoking in relation to lung cancer in women.
Next Document:  CA 125 assay used in conjunction with CA 15-3 and TAG-72 assays for discrimination between malignant...