| Monoamine transporters: vulnerable and vital doorkeepers. | |
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MedLine Citation:
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PMID: 21199769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transporters of dopamine, serotonin, and norepinephrine have been empirically used as medication targets for several mental illnesses in the last decades. These protein-targeted medications are effective only for subpopulations of patients with transporter-related brain disorders. Since the cDNA clonings in early 1990s, molecular studies of these transporters have revealed a wealth of information about the transporters' structure-activity relationship (SAR), neuropharmacology, cell biology, biochemistry, pharmacogenetics, and the diseases related to the human genes encoding these transporters among related regulators. Such new information creates a unique opportunity to develop transporter-specific medications based on SAR, mRNA, DNA, and perhaps transporter trafficking regulation for a number of highly relevant diseases including substance abuse, depression, schizophrenia, and Parkinson's disease. |
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Authors:
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Zhicheng Lin; Juan J Canales; Thröstur Björgvinsson; Morgane Thomsen; Hong Qu; Qing-Rong Liu; Gonzalo E Torres; S Barak Caine |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Progress in molecular biology and translational science Volume: 98 ISSN: 1878-0814 ISO Abbreviation: Prog Mol Biol Transl Sci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-07-27 Revised Date: 2012-04-11 |
Medline Journal Info:
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Nlm Unique ID: 101498165 Medline TA: Prog Mol Biol Transl Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-46 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychiatry, Harvard Medical School and Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior DNA, Complementary / genetics Humans Membrane Transport Proteins / genetics, metabolism* Risk Factors Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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DA016710/DA/NIDA NIH HHS; DA021409/DA/NIDA NIH HHS; DA027825/DA/NIDA NIH HHS; K01 DA016710-04/DA/NIDA NIH HHS; K99 DA027825-01/DA/NIDA NIH HHS; K99 DA027825-02/DA/NIDA NIH HHS; R01 DA021409-05/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/Membrane Transport Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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