| Monoamine oxidase a promoter gene associated with problem behavior in adults with intellectual/developmental disabilities. | |
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MedLine Citation:
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PMID: 19642709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A functional polymorphism in the promoter of the gene encoding monoamine oxidase A has been associated with problem behavior in various populations. We examined the association of MAOA alleles in adult males with intellectual/developmental disabilities with and without established histories of problem behavior. These data were compared with a gender, ethnicity, and age-matched contrast sample. About 43% (15/35) of adults with intellectual/developmental disabilities and problem behavior possessed the low-efficiency version of the MAOA gene. In comparison, 20% (7/35) of adults with intellectual/developmental disabilities and no problem behavior and 20% (7/35) of the contrast group had the short-allele MAOA polymorphism. Therefore, a common variant in the MAOA gene may be associated with problem behavior in adults with intellectual/developmental disabilities. |
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Authors:
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Michael E May; Ali Srour; Lora K Hedges; David A Lightfoot; John A Phillips; Randy D Blakely; Craig H Kennedy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: American journal on intellectual and developmental disabilities Volume: 114 ISSN: 1944-7515 ISO Abbreviation: - Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-31 Completed Date: 2009-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101492916 Medline TA: Am J Intellect Dev Disabil Country: Unknown |
Other Details:
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Languages: eng Pagination: 269-73 Citation Subset: IM |
Affiliation:
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Southern Illinois University, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alleles* Comorbidity Developmental Disabilities / epidemiology, genetics* Female Genotype Humans Male Mental Disorders / diagnosis, epidemiology, genetics* Mental Retardation / diagnosis, epidemiology, genetics* Middle Aged Minisatellite Repeats / genetics Monoamine Oxidase / genetics* Polymorphism, Genetic / genetics* Promoter Regions, Genetic / genetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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