Document Detail


Monoamine oxidase molecular activity in platelets of parkinsonian and demented patients.
MedLine Citation:
PMID:  9117547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Platelet monoamine oxidase activity levels have been evaluated in several neuropsychiatric disorders, to identify biochemical markers for pathological brain functioning. In the present work, we assayed both total and molecular monoamine oxidase activity in platelets of parkinsonian and demented patients: both showed significantly higher enzyme activity values than healthy controls. Thus, high platelet monoamine oxidase activity levels seem to be related to an increased intrinsic activity of single enzyme molecules. A significant positive correlation was found between platelet monoamine oxidase activity and severity of illness in both disorders: monoamine oxidase activity, therefore, may be considered as a state-dependent marker for neuro-degeneration. Such findings are discussed with reference to central nervous system biochemical abnormalities in parkinsonian and demented subjects; it might be that in both Parkinson's Disease and in dementia of Alzheimer type some central biochemical changes are reflected in certain peripheral tissues (thrombocytes, for instance), or that a systemic derangement accompanies the cerebral involvement.
Authors:
P Bongioanni; C Mondino; B Boccardi; M Borgna; M Castagna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration     Volume:  5     ISSN:  1055-8330     ISO Abbreviation:  Neurodegeneration     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9209022     Medline TA:  Neurodegeneration     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  IM    
Affiliation:
Scuola Superiore di Studi Universitari e di Perfezionamento, Pisa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / blood*
Blood Platelets / enzymology*
Female
Humans
Male
Middle Aged
Monoamine Oxidase / blood*
Parkinson Disease, Secondary / blood*
Reference Values
Chemical
Reg. No./Substance:
EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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