Document Detail

Monoamine oxidase inhibitor dietary restrictions: what are we asking patients to give up?
MedLine Citation:
PMID:  7737959     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Though the list of possible indications for monoamine oxidase inhibitors (MAOIs) continues to expand, many psychiatrists remain hesitant about prescribing MAOIs, citing concerns about dietary prohibitions and hypertensive reactions. Data about psychiatric patients' frequency of consumption of foods, beverages, and medications prohibited during MAOI use are lacking. METHOD: We conducted a survey of 139 psychiatric patients admitted to either an inpatient unit specializing in the treatment of mood disorders or an outpatient anxiety disorders clinic specializing in the treatment of social phobia. At inclusion, patients were not being treated with MAOIs, although they might have received such treatment afterward. All patients completed a self-report questionnaire created for this study to ascertain their consumption of food, beverage, and medication items frequently found on MAOI diet lists. Demographic and diagnostic information was also recorded. RESULTS: The most frequently used high-risk items were the hard cheeses. Ninety percent of patients reported daily or weekly consumption of some food containing cheese, while less than 1% of patients reported never eating hard cheese. Yeast products, dry sausage, corned beef, broad beans, sauerkraut, and beer were used at least monthly by more than 50% of patients. Of the intermediate-risk foods, chocolate was the most frequently consumed, with almost 30% of the patients eating some chocolate daily. Over 40% of patients reported using over-the-counter cold preparations on a monthly basis. CONCLUSION: A wide variety of tyramine-containing foods and contraindicated medications were commonly used by our patients prior to evaluation for possible MAOI pharmacotherapy. The number and diversity of frequently consumed items do not support recommendations to reduce the breadth of restrictions in MAOI diets. Individually targeted dietary assessment and education are recommended to reduce the risks of prescribing MAOIs.
R A Sweet; E J Brown; R G Heimberg; L Ciafre; D M Scanga; J R Cornelius; S Dube; K M Forsyth; C S Holt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  56     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  196-201     Citation Subset:  IM    
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA.
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MeSH Terms
Beverages / adverse effects
Cheese / adverse effects
Depressive Disorder / drug therapy,  psychology
Diet Surveys*
Drug Interactions
Food / adverse effects
Food Habits*
Food, Formulated / utilization
Hypertension / chemically induced
Monoamine Oxidase Inhibitors / administration & dosage*,  adverse effects
Nonprescription Drugs / administration & dosage,  adverse effects
Phobic Disorders / drug therapy,  psychology
Risk Assessment
Grant Support
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 0/Nonprescription Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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