Document Detail

Monoamine oxidase inhibition and brain amine metabolism after oral treatment with toloxatone in the rat.
MedLine Citation:
PMID:  41906     Owner:  NLM     Status:  MEDLINE    
Rats were administered toloxatone 100 mg kg-1 p.o., and killed 0.5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were reduced. Synaptosomal uptake processes of these amines were not altered by tolaxatone.
P E Keane; J P Kan; N Sontag; M S Benedetti
Related Documents :
12676606 - Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and r...
8417136 - Extracellular dopamine and serotonin in the rat striatum during transient ischaemia of ...
6349516 - Effect of sodium glycolate and sodium pyruvate on oxalic acid biosynthesizing enzymes i...
7268806 - Effects of the pyrrolizidine alkaloids senecionine, retrorsine and seneciphylline on am...
956926 - Effect of vitamin b6 deficiency on collagen metabolism in rats.
15812576 - Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopon...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  31     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  752-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antidepressive Agents / pharmacology*
Biogenic Amines / metabolism*
Brain / drug effects,  metabolism*,  ultrastructure
Dopamine / metabolism
Monoamine Oxidase Inhibitors*
Norepinephrine / metabolism
Oxazoles / pharmacology*
Serotonin / metabolism
Synaptosomes / metabolism
Time Factors
Reg. No./Substance:
0/Antidepressive Agents; 0/Biogenic Amines; 0/Monoamine Oxidase Inhibitors; 0/Oxazoles; 50-67-9/Serotonin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of acute or chronic administration of chlordiazepoxide on feeding parameters using two food ...
Next Document:  Selective influences of age and thyroid hormones on type A monoamine oxidase of the rat heart.