Document Detail


Monoamine oxidase inhibition and brain amine metabolism after oral treatment with toloxatone in the rat.
MedLine Citation:
PMID:  41906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats were administered toloxatone 100 mg kg-1 p.o., and killed 0.5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were reduced. Synaptosomal uptake processes of these amines were not altered by tolaxatone.
Authors:
P E Keane; J P Kan; N Sontag; M S Benedetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  31     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  752-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents / pharmacology*
Biogenic Amines / metabolism*
Brain / drug effects,  metabolism*,  ultrastructure
Deamination
Dopamine / metabolism
Male
Monoamine Oxidase Inhibitors*
Norepinephrine / metabolism
Oxazoles / pharmacology*
Oxidation-Reduction
Rats
Serotonin / metabolism
Synaptosomes / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Biogenic Amines; 0/Monoamine Oxidase Inhibitors; 0/Oxazoles; 50-67-9/Serotonin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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