Document Detail


Monoamine oxidase inhibiting and toxic effects of acetyl-phenylhydrazide on rat liver in vivo.
MedLine Citation:
PMID:  288344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For induction of reticulocytosis, rats had been routinely treated with the haemolytic agent, acetyl-phenylhydrazide (APH), and monoamine oxidase (MAO) activity was determined in reticulocytes. Since hydrazines are known to be irreversible inhibitors of MAO, the MAO inhibiting potency of APH was assessed in vitro and in vivo. Only in vivo, an apparently organ-selective MAO inhibition was observed in rat liver; in addition, the rate of recovery of MAO activity in vivo after inhibition with APH was considerably prolonged, indicating a toxic effect of APH on this organ. However, clinical-chemical and pathohistological parameters did not reveal any signs of an overall liver parenchymal cell damage. Hence, a more specific interference of APH with mitochondrial enzyme synthesis must be postulated.
Authors:
K Quiring; V Schmidt; H Christen; L Hamm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement     Volume:  -     ISSN:  0171-9750     ISO Abbreviation:  Arch. Toxicol. Suppl.     Publication Date:  1979  
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802567     Medline TA:  Arch Toxicol Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  355-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bilirubin / metabolism
Creatinine / pharmacology
Liver / drug effects*,  enzymology
Monoamine Oxidase Inhibitors*
Phenylhydrazines / pharmacology*,  toxicity
Rats
Time Factors
Chemical
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 0/Phenylhydrazines; 60-27-5/Creatinine; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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