Document Detail


Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity.
MedLine Citation:
PMID:  3137508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.
Authors:
J Willoughby; V Glover; M Sandler; A Albanese; P Jenner; C D Marsden
Related Documents :
6527138 - Monoamine oxidase in young and adult rat brain capillaries.
7098148 - Hyperuricemic effects of cholinergic agents in rats.
10670778 - Reduced number of striatal neurons expressing preprosomatostatin mrna in rats with oral...
8053938 - Propyl gallate as a hepatoprotector in vitro and in vivo.
6143858 - The pull-up test in rats: a simple method for evaluating muscle relaxation.
17228268 - High-frequency monopolar electrical stimulation of the rat cerebral cortex.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  90     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-13     Completed Date:  1988-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  100-6     Citation Subset:  IM    
Affiliation:
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital, London, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Brain / enzymology*
Callitrichinae / metabolism*
Female
Histocytochemistry
Monoamine Oxidase / analysis*
Pyridines / toxicity*
Rats
Chemical
Reg. No./Substance:
0/Pyridines; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in parkinsonian pat...
Next Document:  Autoradiographic distribution of [3H]acetylcholine binding sites in the cervical spinal cord of man ...