Document Detail

Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity.
MedLine Citation:
PMID:  3137508     Owner:  NLM     Status:  MEDLINE    
This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.
J Willoughby; V Glover; M Sandler; A Albanese; P Jenner; C D Marsden
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  90     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-13     Completed Date:  1988-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  100-6     Citation Subset:  IM    
Bernhard Baron Memorial Research Laboratories, Queen Charlotte's Hospital, London, U.K.
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MeSH Terms
Brain / enzymology*
Callitrichinae / metabolism*
Monoamine Oxidase / analysis*
Pyridines / toxicity*
Reg. No./Substance:
0/Pyridines; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; EC Oxidase

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