Document Detail

Monoamine neurons in aging and Alzheimer's disease.
MedLine Citation:
PMID:  8099796     Owner:  NLM     Status:  MEDLINE    
The integrity of dopaminergic, noradrenergic and serotonergic neurons in normal aging and Alzheimer's disease is reviewed. Loss of dopaminergic innervation of the neostriatum is a prominent age-related change, which corresponds with the age-related loss of dopaminergic cell bodies from the substantia nigra. This change is regionally specific, since dopaminergic innervation of the neocortex and the neostriatum are not affected. Although there is an age-related loss of noradrenergic cell bodies from the locus coeruleus, most studies indicate normal concentrations of noradrenaline in target areas. There is also evidence for reduced serotonergic innervation of the neocortex and, less convincingly, the neostriatum. Alzheimer's disease is associated with more pronounced noradrenergic and serotonergic denervation but, unlike normal aging, dopaminergic innervation of neostriatum is intact; although dopamine neurons are probably dysfunctional in this region. Studies relating neuronal markers to the symptomatology of Alzheimer's disease indicate that dysfunction of monoamine neurons is more closely linked to non-cognitive than to cognitive changes in behavior. In addition, monoaminergic therapies have been successful in ameliorating affective and psychotic behaviors along with sleep disturbances in both Alzheimer's disease and senescence. It seems likely that monoaminergic therapies (developed as we learn more about alterations in dopamine, noradrenaline and serotonin) will continue to be necessary to treat such behavioral disturbances.
A M Palmer; S T DeKosky
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  91     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1993  
Date Detail:
Created Date:  1993-07-16     Completed Date:  1993-07-16     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  135-59     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aging / pathology,  physiology*
Alzheimer Disease / pathology,  physiopathology*
Antipsychotic Agents / therapeutic use
Behavior / physiology
Brain Chemistry
Cell Count
Cell Death
Cognition / physiology
Dementia / drug therapy,  pathology,  physiopathology
Dopamine / deficiency,  physiology*
Free Radicals
Middle Aged
Monoamine Oxidase / physiology
Monoamine Oxidase Inhibitors / therapeutic use
Neurons / chemistry,  pathology,  physiology*
Norepinephrine / physiology*
Serotonin / physiology*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Free Radicals; 0/Monoamine Oxidase Inhibitors; 333DO1RDJY/Serotonin; EC Oxidase; VTD58H1Z2X/Dopamine; X4W3ENH1CV/Norepinephrine

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