Document Detail

Monoamine metabolites in the cerebrospinal fluid in infantile spinal muscular atrophy.
MedLine Citation:
PMID:  8061291     Owner:  NLM     Status:  MEDLINE    
Analyses of tryptophan and tyrosine metabolites in cerebrospinal fluid were performed to examine an abnormality of the monoamine neurone system in severe infantile spinal muscular atrophy (SMA type I). The levels of 5-hydroxyindoleacetic acid and homovanillic acid were significantly lower than those in controls. Decreases in the concentration of 5-hydroxyindoleacetic acid and kynurenine seemed to be related to the severity of SMA type I. These results suggest that the monoamine neurone system may play a role in the pathophysiology of SMA type I.
Y Takeuchi; H Komatsu; S Matsuo; K Hirai; S Kawase; A Nishimura; T Sawada
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  5     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-19     Completed Date:  1994-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  898-900     Citation Subset:  IM    
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Biogenic Monoamines / cerebrospinal fluid*
Infant, Newborn
Spinal Muscular Atrophies of Childhood / cerebrospinal fluid*
Tryptophan / cerebrospinal fluid
Tyrosine / cerebrospinal fluid
Reg. No./Substance:
0/Biogenic Monoamines; 55520-40-6/Tyrosine; 73-22-3/Tryptophan

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