Document Detail

Monoamine metabolites in cerebrospinal fluid during and after acute cerebral ischemia.
MedLine Citation:
PMID:  2472800     Owner:  NLM     Status:  MEDLINE    
In order to understand the role of monoamines in cerebral ischemia, 3-methoxy-4-hydroxyphenylglycol(MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid(HVA), the three major unconjugated monoamine metabolites in cerebrospinal fluid (CSF), of 33 patients and 18 controls were measured with high performance liquid chromatography. Results showed all three metabolites were raised in patients with severe ischemia, but only MHPG and 5-HIAA were elevated significantly, MHPG changes more quickly and regularly as a consequence of cerebral ischemia than the two others. A positive correlation between any pair of metabolites was found in controls and in patients in the first week after stroke, but not at the end of the second week. Computer assisted multivariate analysis indicated 5-HIAA and MHPG correlated more closely with the state of illness in the acute stage, whereas HVA correlated the least. Possible explanations for the changes of CSF levels of amine metabolites are discussed.
H Z Tang; X F Lu; K J Wang; S Ouyang; Y Q Huang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid     Volume:  10     ISSN:  1044-7393     ISO Abbreviation:  Mol. Chem. Neuropathol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-15     Completed Date:  1989-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8910358     Medline TA:  Mol Chem Neuropathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-85     Citation Subset:  IM    
Department of Neurology, First Affiliated Hospital, Hunan Medical University, People's Republic of China.
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MeSH Terms
Biogenic Monoamines / cerebrospinal fluid
Glycols / cerebrospinal fluid*
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Ischemic Attack, Transient / cerebrospinal fluid*
Methoxyhydroxyphenylglycol / cerebrospinal fluid*
Middle Aged
Reg. No./Substance:
0/Biogenic Monoamines; 0/Glycols; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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