Document Detail


Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment.
MedLine Citation:
PMID:  2480613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The monoamine metabolites (MAM) homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA), 4-hydroxy-3-methoxy-phenylglycol (HMPG) and the amino acids tyrosine, tryptophan, glutamate and glutamine were measured in serum before treatment and once a week during treatment. There were no significant differences between healthy controls and schizophrenic patients in serum levels of monoamine metabolites and amino acids before treatment. There was no dose-response effect of sulpiride on serum levels of the monoamine metabolites or the amino acids. The results are therefore based on the whole group of patients. During treatment the HMPG levels were reduced at all points in time. The serum level of HVA was significantly reduced after 6 weeks. The 5-HIAA and the amino acid levels were not changed during treatment. There were no significant correlations among the monoamine metabolites before treatment. During treatment, however, significant correlations were found among MAM and amino acids. Since the biochemical findings during the treatment were not related to the dose or the concentration of sulpiride the results may be related to secondary biochemical effects of sulpiride and/or to changes in the clinical state following treatment.
Authors:
G Alfredsson; F A Wiesel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  99     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  322-7     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Psychology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amino Acids / blood*
Biogenic Monoamines / blood*
Female
Glutamates / blood,  cerebrospinal fluid
Glutamine / blood
Homovanillic Acid / blood
Humans
Hydroxyindoleacetic Acid / blood
Male
Meglutol / cerebrospinal fluid
Schizophrenia / blood*,  cerebrospinal fluid,  drug therapy
Sulpiride / blood,  therapeutic use*
Tryptophan / blood
Tyrosine / blood
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Monoamines; 0/Glutamates; 15676-16-1/Sulpiride; 306-08-1/Homovanillic Acid; 503-49-1/Meglutol; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 56-85-9/Glutamine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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