Document Detail


Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus.
MedLine Citation:
PMID:  12121816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Subarachnoid haemorrhage is a serious condition, often accompanied by cerebral vasospasm and hydrocephalus, which may result in delayed cerebral ischaemia and neurological deterioration. While the mechanisms responsible remain unknown, activation of the sympathetic nervous system, leading to elevated levels of circulating catecholamines is, at least in part, implicated. In this study, we sought to examine the importance of sympathetic nervous activation and its relation to brain monoaminergic neurotransmission in 25 patients following subarachnoid haemorrhage by examining plasma and cerebrospinal fluid levels of the catecholamines noradrenaline, adrenaline and dopamine, and their metabolites. Total body sympathetic activity was concurrently assessed using isotope dilution methodology. In the early phase following subarachnoid haemorrhage patients exhibited markedly elevated rates of spillover of noradrenaline to plasma (9.11 +/- 1.12 vs. 3.39 +/- 0.26 nmol/min, p < 0.01), with rates being higher in those patients in whom hydrocephalus developed (11.15 +/- 1.40 vs. 7.90 +/- 1.41 nmol/min, p = 0.05). The degree of sympathetic nervous activation tended to be higher in females compared with males. Lower cerebral perfusion pressures were observed in those patients in whom cerebrospinal fluid concentrations of noradrenaline and dopamine metabolites were high. A marked sympathetic nervous activation, more pronounced in women and in those with hydrocephalus, occurs following subarachnoid haemorrhage. The diminished cerebral perfusion seen following subarachnoid bleeding may occur as a result of activation of central catecholaminergic neurones.
Authors:
Gavin Lambert; Silvana Naredi; Elisabeth Edén; Bertil Rydenhag; Peter Friberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  58     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-10-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Inc.
Affiliation:
Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenbourg, Sweden. gavin.lambert@baker.edu.au
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / blood
Adult
Aged
Biogenic Monoamines / blood*,  cerebrospinal fluid
Craniocerebral Trauma / blood,  cerebrospinal fluid
Dihydroxyphenylalanine / blood
Dopamine / blood,  cerebrospinal fluid
Epinephrine / blood,  cerebrospinal fluid
Female
Homovanillic Acid / cerebrospinal fluid
Humans
Hydrocephalus / blood*,  cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Male
Methoxyhydroxyphenylglycol / analogs & derivatives*,  blood,  cerebrospinal fluid
Middle Aged
Norepinephrine / blood,  cerebrospinal fluid
Sex Factors
Subarachnoid Hemorrhage / blood*,  cerebrospinal fluid
Sympathetic Nervous System / metabolism*
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 3343-19-9/dihydroxyphenylethylene glycol; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 63-84-3/Dihydroxyphenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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