| Monoamine mechanisms in chronic schizophrenia: post-mortem neurochemical findings. | |
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MedLine Citation:
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PMID: 41609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dopamine and its metabolites homovanillic acid and dihydroxyphenylacetic acid, noradrenaline, serotonin and its metabolite 5-hydroxyindoleacetic acid, and tryptophan and its metabolite kynurenine have been assayed in 9 schizophrenic and 10 control brains, together with the monoamine-related enzymes tyrosine hydroxylase monoamine oxidase, dopamine-beta-hydroxylase, and catechol-o-methyl-transferase. In schizophrenic brains dopamine, noradrenaline and serotonin were significantly increased in some areas of corpus striatum, but there were no significant changes in enzyme activity or monoamine metabolite concentrations in any of the brain areas examined. The findings are not consistent with theories that serotonin or noradrenaline stores are grossly depleted or noradrenaline neurones have degenerated, or that monoamine oxidase activity is abnormal, in schizophrenia, and provide no direct support for the hypothesis that dopamine neurones are overactive. |
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Authors:
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T J Crow; H F Baker; A J Cross; M H Joseph; R Lofthouse; A Longden; F Owen; G J Riley; V Glover; W S Killpack |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 134 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 1979 Mar |
Date Detail:
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Created Date: 1980-02-28 Completed Date: 1980-02-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 249-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Chemistry* Catechol O-Methyltransferase / analysis Chronic Disease Dopamine / analysis* Dopamine beta-Hydroxylase / analysis Female Humans Hydroxyindoleacetic Acid / analysis Kynurenine / analysis Male Monoamine Oxidase / analysis Norepinephrine / analysis* Phenylacetates / analysis Schizophrenia / metabolism* Serotonin / analysis* Tryptophan / analysis* Tyrosine 3-Monooxygenase / analysis |
| Chemical | |
Reg. No./Substance:
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0/Phenylacetates; 343-65-7/Kynurenine; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 73-22-3/Tryptophan; EC 1.14.16.2/Tyrosine 3-Monooxygenase; EC 1.14.17.1/Dopamine beta-Hydroxylase; EC 1.4.3.4/Monoamine Oxidase; EC 2.1.1.6/Catechol O-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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