Document Detail

Monoamine levels in the nucleus accumbens correlate with male sexual behavior in middle-aged rats.
MedLine Citation:
PMID:  16529800     Owner:  NLM     Status:  MEDLINE    
The correlation between monoamine levels in the nucleus accumbens (NAcc) and male sexual behavior was studied in middle-aged rats. Male rats (18-19months) were assigned to three groups: (1) Group MIE consisted of rats showing mounts, intromissions, and ejaculations; (2) Group MI was composed of rats showing mounts and intromissions, but no ejaculation; and (3) Group NC were non-copulators showing no sexual behavior. Young adult rats (4-5months), displaying complete copulatory behavior, were used as the control group. Levels of dopamine (DA), serotonin, and norepinephrine and their metabolites in the NAcc were measured by high-pressure liquid chromatography with electrochemical detection. No difference was seen in DA levels between MIE rats and young controls, whereas DA levels in NC rats were significantly lower than those in both MIE and MI rats. Serotonin levels in NC rats were significantly higher than those in MIE and MI rats. Conversely, norepinephrine levels in NC rats were lower than those in MIE rats. These results suggest that monoamine levels in the NAcc correlate with sexual performance in male rats and that changes in NAcc monoamine levels might affect male sexual behavior in middle-aged rats.
Houng-Wei Tsai; Hao-Ai Shui; Hang-Shen Liu; Mei-Yun Tai; Yuan-Feen Tsai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-09
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  83     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  IM    
Department of Physiology, College of Medicine, National Taiwan University, No.1 Jen-Ai Road, 1st Section, Taipei, Taiwan (100), ROC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biogenic Monoamines / metabolism*
Chromatography, High Pressure Liquid
Dopamine / metabolism
Nucleus Accumbens / metabolism*
Rats, Long-Evans
Serotonin / metabolism
Sexual Behavior, Animal*
Reg. No./Substance:
0/Biogenic Monoamines; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gender specific effects of a mild stressor on alcohol cue reactivity in heavy social drinkers.
Next Document:  Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.