Document Detail


Monoaminc and metabolite levels in the cerebrospinal fluid of hibernating and euthermic marmots.
MedLine Citation:
PMID:  10607025     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cerebrospinal fluid from yellow-bellied marmots, Marmota flaviventris, was analysed for monoamine and monoamine metabolite content during euthermia and deep hibernation. Dopamine (DA) levels were decreased, while DA metabolite levels, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), were dramatically increased in hibernating marmots. Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5HIAA) levels were also greatly enhanced during hibernation while norepinephrine (NE) levels were only moderately increased. These findings demonstrate that cerebrospinal monoamine levels are dynamically altered during hibernation, such that DA versus 5-HT and NE levels undergo opposite changes. Therefore, these data indicate that DA, 5-HT and NE neuronal systems are differentially altered during hibernation in mammals.
Authors:
Reid; Kilduff; Romero; Florant; Dement; Heller
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of sleep research     Volume:  1     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1999-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  45-50     Citation Subset:  -    
Affiliation:
Stanford University Sleep Disorders Research Center, Palo Alto, USA.
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