| Monoaminc and metabolite levels in the cerebrospinal fluid of hibernating and euthermic marmots. | |
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MedLine Citation:
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PMID: 10607025 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cerebrospinal fluid from yellow-bellied marmots, Marmota flaviventris, was analysed for monoamine and monoamine metabolite content during euthermia and deep hibernation. Dopamine (DA) levels were decreased, while DA metabolite levels, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), were dramatically increased in hibernating marmots. Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5HIAA) levels were also greatly enhanced during hibernation while norepinephrine (NE) levels were only moderately increased. These findings demonstrate that cerebrospinal monoamine levels are dynamically altered during hibernation, such that DA versus 5-HT and NE levels undergo opposite changes. Therefore, these data indicate that DA, 5-HT and NE neuronal systems are differentially altered during hibernation in mammals. |
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Authors:
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Reid; Kilduff; Romero; Florant; Dement; Heller |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of sleep research Volume: 1 ISSN: 1365-2869 ISO Abbreviation: J Sleep Res Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1999-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214441 Medline TA: J Sleep Res Country: - |
Other Details:
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Languages: ENG Pagination: 45-50 Citation Subset: - |
Affiliation:
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Stanford University Sleep Disorders Research Center, Palo Alto, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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