Document Detail


Monoacylglycerol (MAG)-oleic acid has stronger antioxidant, anti-atherosclerotic, and protein glycation inhibitory activities than MAG-palmitic acid.
MedLine Citation:
PMID:  20136442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A functional oil containing diacylglycerol (DAG) and monoacylglycerol (MAG) has been shown to have a strong anti-atherosclerotic effect in a mouse model. Among the lipid components, MAG is responsible for the beneficial effect with an enhanced antioxidant effect in the mouse model. In this report, several MAG-containing fatty acids (MAG-oleic acid [MAG-O], MAG-palmitic acid [MAG-P], and MAG-stearic acid [MAG-S]) were synthesized, and the antioxidant and anti-atherogenic activities were evaluated in vitro and in a cellular model. MAG-O had the strongest radical scavenging and antioxidant activities against copper-mediated low-density lipoprotein (LDL) oxidation and the strongest inhibitory activity against LDL-associated phospholipase A(2) and exhibited potent activation of paraoxonase activity, which contributes to the maintenance of antioxidant activity. All MAG species in this study exhibited inhibitory activity against glycation of apolipoproteins, in contrast to DAG. Oxidized LDL uptake into THP-1 cells was strongly inhibited by MAG-O treatment at a final concentration of 20 microM. MAG-O-treated cell culture medium showed the lowest production of malondialdehyde and lipid hydroperoxide compared to MAG-S and MAG-P. In conclusion, MAG-O had potent antioxidant, antidiabetic, and anti-atherogenic effects in vitro and in a cellular model.
Authors:
Kyung-Hyun Cho; Joo-Heon Hong; Ki-Teak Lee
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  13     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-107     Citation Subset:  IM    
Affiliation:
School of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea. chok@yu.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / pharmacology*
Apolipoproteins / metabolism*
Aryldialkylphosphatase / metabolism
Atherosclerosis / prevention & control*
Cell Line
Cholesterol, LDL / metabolism
Dietary Fats / pharmacology*
Fatty Acids / pharmacology*,  therapeutic use
Functional Food
Glycosylation
Humans
Lipid Peroxidation / drug effects*
Lipid Peroxides / metabolism
Male
Malondialdehyde / metabolism
Monoglycerides / pharmacology*,  therapeutic use
Oleic Acid / pharmacology,  therapeutic use
Palmitic Acid / pharmacology,  therapeutic use
Phospholipases A2 / metabolism
Stearic Acids / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Apolipoproteins; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Fatty Acids; 0/Lipid Peroxides; 0/Monoglycerides; 0/Stearic Acids; 112-80-1/Oleic Acid; 542-78-9/Malondialdehyde; 57-10-3/Palmitic Acid; 57-11-4/stearic acid; EC 3.1.1.4/Phospholipases A2; EC 3.1.8.1/Aryldialkylphosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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