| Monoacylglycerol (MAG)-oleic acid has stronger antioxidant, anti-atherosclerotic, and protein glycation inhibitory activities than MAG-palmitic acid. | |
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MedLine Citation:
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PMID: 20136442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A functional oil containing diacylglycerol (DAG) and monoacylglycerol (MAG) has been shown to have a strong anti-atherosclerotic effect in a mouse model. Among the lipid components, MAG is responsible for the beneficial effect with an enhanced antioxidant effect in the mouse model. In this report, several MAG-containing fatty acids (MAG-oleic acid [MAG-O], MAG-palmitic acid [MAG-P], and MAG-stearic acid [MAG-S]) were synthesized, and the antioxidant and anti-atherogenic activities were evaluated in vitro and in a cellular model. MAG-O had the strongest radical scavenging and antioxidant activities against copper-mediated low-density lipoprotein (LDL) oxidation and the strongest inhibitory activity against LDL-associated phospholipase A(2) and exhibited potent activation of paraoxonase activity, which contributes to the maintenance of antioxidant activity. All MAG species in this study exhibited inhibitory activity against glycation of apolipoproteins, in contrast to DAG. Oxidized LDL uptake into THP-1 cells was strongly inhibited by MAG-O treatment at a final concentration of 20 microM. MAG-O-treated cell culture medium showed the lowest production of malondialdehyde and lipid hydroperoxide compared to MAG-S and MAG-P. In conclusion, MAG-O had potent antioxidant, antidiabetic, and anti-atherogenic effects in vitro and in a cellular model. |
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Authors:
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Kyung-Hyun Cho; Joo-Heon Hong; Ki-Teak Lee |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-08 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 99-107 Citation Subset: IM |
Affiliation:
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School of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea. chok@yu.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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pharmacology* Apolipoproteins / metabolism* Aryldialkylphosphatase / metabolism Atherosclerosis / prevention & control* Cell Line Cholesterol, LDL / metabolism Dietary Fats / pharmacology* Fatty Acids / pharmacology*, therapeutic use Functional Food Glycosylation Humans Lipid Peroxidation / drug effects* Lipid Peroxides / metabolism Male Malondialdehyde / metabolism Monoglycerides / pharmacology*, therapeutic use Oleic Acid / pharmacology, therapeutic use Palmitic Acid / pharmacology, therapeutic use Phospholipases A2 / metabolism Stearic Acids / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Apolipoproteins; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Fatty Acids; 0/Lipid Peroxides; 0/Monoglycerides; 0/Stearic Acids; 112-80-1/Oleic Acid; 542-78-9/Malondialdehyde; 57-10-3/Palmitic Acid; 57-11-4/stearic acid; EC 3.1.1.4/Phospholipases A2; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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