| Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers. | |
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MedLine Citation:
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PMID: 21182165 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Apoptosis is the primary mechanism through which most chemotherapeutic agents induce tumor cell death. The purpose of this study was to monitor the expression of pro- and anti-apoptotic proteins CD(95) , Bcl-2, as well as copper and zinc levels in the peripheral blood of children with acute lymphocytic leukemia (ALL) prior to and 6 months after the beginning of chemotherapy. Blood parameters and bone marrow blast count were also assessed. Twenty of 26 patients who received treatment showed amelioration in apoptotic response, which is reflected in the elevation of CD(95) , whereas Bcl-2 protein was significantly lowered. In these patients, the elevated serum copper level was not significantly affected whereas the low serum zinc level was significantly raised. Improvement in blood parameters and bone marrow blast count were also achieved. Taken together, the data suggested that assessment of apoptosis signaling molecules might have a predictive impact on treatment outcome. |
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Authors:
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Maged Barakat; Zakareya Elkhayat; Naglaa Kholoussi; Hala Elnady; Manal Ismail; Jackleen Raafat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biochemical and molecular toxicology Volume: 24 ISSN: 1099-0461 ISO Abbreviation: J. Biochem. Mol. Toxicol. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717231 Medline TA: J Biochem Mol Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 343-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley Periodicals, Inc. |
Affiliation:
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Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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