Document Detail

Monitoring of skin response to sodium lauryl sulphate: clinical scores versus bioengineering methods.
MedLine Citation:
PMID:  1451459     Owner:  NLM     Status:  MEDLINE    
The present trial was designed to evaluate clinical scores (single observer) of sodium lauryl sulphate (SLS)-induced skin irritation in a group of subjects (n = 10) over a 10-day period along with various skin function parameters. In order to avoid significant variations due to secondary phenomena, the following parameters were recorded with non-invasive instruments in this order: skin capacitance (C1; arbitrary units; CM420 Corneometer), transepidermal water loss (TEWL; g/m2.h; Evaporimeter) and laser Doppler flowmetry (CBFV: cutaneous blood flow values; Periflux). All examinations were performed during winter on reclined relaxed subjects present for at least 10 min in a test room with controlled temperature and relative humidity (t degrees: 19.5-20.7 degrees C and RH: 47.3-60.3%). The analysis of differential data (delta = value at tx-value before test; 2-way ANOVA) was made on single parameters as a function of site (volar forearm versus neck) and time (from 24 h after 48-h occlusion with 5% SLS up to 10 days later). The profile of erythema scores over time differed between neck and forearm, but the delta CBFV readings with the laser Doppler instrument did not detect significant site-time interactions. Roughness (blind evaluation with palpating finger) and capacitance readings (delta C1) showed significant differences between sites, but the profile over time was similar in both locations. delta TEWL did not differ according to anatomical location. The reason for different erythema scores on neck and forearm might be related to inherent regional variation of optical properties of the skin or to a substantial contribution of SLS-induced roughness to the readings of erythema.(ABSTRACT TRUNCATED AT 250 WORDS)
D van Neste; B de Brouwer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  27     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-01-07     Completed Date:  1993-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  IM    
Skin Study Center, Skinterface, Tournai, Belgium.
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MeSH Terms
Dermatitis, Irritant / diagnosis*,  etiology
Electric Conductivity
Erythema / diagnosis
Laser-Doppler Flowmetry
Monitoring, Physiologic
Patch Tests
Skin / drug effects*,  pathology,  physiopathology
Sodium Dodecyl Sulfate / adverse effects*
Reg. No./Substance:
151-21-3/Sodium Dodecyl Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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