Document Detail


Monitoring of plasma cell proliferative and apoptotic indices in the course of multiple myeloma.
MedLine Citation:
PMID:  19860618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a group of 310 patients with multiple myeloma (MM) we assessed the proliferative (PC-PI) and apoptotic indices (PC-AI). Patients were divided according to the disease state, i.e. at the time of diagnosis, in relapse, and in MM remission. We assessed the behavior of both indices with respect to therapy response and activity of the disease. In patients who reached remission, there was a significant decrease of PC-PI together with an increase of PC-AI in comparison with initial measurements. In non-responders, there was a reverse trend with increasing PC-PI and decreasing PC-AI. The values of PC-PI and PC-AI in residual myeloma population were similar regardless of treatment, i.e. in patients treated using conventional chemotherapy and after high-dosed chemotherapy with autologous stem cell transplant. Patients in long-lasting remission phase maintained stable low values of PC-PI with high PC-AI without a significant change, whereas in the group of progressing/relapsing patients, there was a significant increase of PC-PI together with a decrease of PC-AI. Our results suggest that longitudinal measurement of proliferative and apoptotic indices in MM plasmocytes helps to estimate the behavior of the tumor population and may thus become a convenient auxiliary parameter for prognosis and a targeted, individualized treatment approach.
Authors:
Jiri Minarik; Vlastimil Scudla; Marta Ordeltova; Jaroslav Bacovsky; Tomas Pika; Katerina Langova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  50     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1983-91     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine III, University Hospital Olomouc, Czech Republic. abretina@email.cz
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Apoptosis*
Cell Proliferation*
Combined Modality Therapy
Female
Humans
Logistic Models
Male
Middle Aged
Mitotic Index
Multiple Myeloma / therapy*
Outcome Assessment (Health Care)
Plasma Cells / pathology*
Prognosis
Stem Cell Transplantation / methods
Transplantation, Autologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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