| Monitoring oxygen delivery in the critically ill. | |
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MedLine Citation:
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PMID: 16306053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An accurate assessment of regional tissue oxygen delivery (DO(2)) may help the intensivist to attenuate end-organ damage in critically ill patients. Transport of oxygen from the ambient air to the mitochondria occurs by convection and diffusion, and is tightly regulated by neural and humoral factors. This article reviews the basic principles of DO(2) and the abnormal oxygen supply-demand relationship seen in patients with shock. It also discusses approaches to monitoring DO(2), including clinical symptoms/signs, acid-base status, and gas exchange, which provide global assessment, as well as gastric tonometry, which may reflect regional DO(2). Some new experimental methods, such as near-infrared spectroscopy and positron emission tomography, are still in development but may in the future provide useful clinical devices for quantifying the adequacy of regional tissue oxygenation in critically ill patients. |
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Authors:
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Yuh-Chin Tony Huang |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Chest Volume: 128 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-24 Completed Date: 2005-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 554S-560S Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary & Critical Care Medicine, Box 3315, Duke University Medical Center, Durham, NC 27710, USA. huang002@mc.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Anoxia / physiopathology Critical Illness* Humans Oxygen / blood, metabolism* Oxygen Consumption Pulmonary Gas Exchange Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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