Document Detail

Monitoring of nonlinear respiratory elastance using a multiple linear regression analysis.
MedLine Citation:
PMID:  11491159     Owner:  NLM     Status:  MEDLINE    
The elastic pressure/volume (P/V) curve obtained by the multiple linear regression (MLR) technique using a new model, was compared with the quasi-static P/V points obtained by the rapid airway occlusion technique. Seven infants were studied during mechanical ventilation using a pressure controlled mode. The resistive pressure was subtracted from airway opening pressure, thus determining the elastance related pressure, which was then plotted against the volume to make an MLR-elastance curve. Quasi-static P/V curves of the rapid occlusion technique were constructed by plotting the different inspiratory and expiratory volumes against the corresponding values of the quasi-static airway pressure. The calculated MLR-elastance curves closely fit the experimental quasi-static P/V points obtained by the occlusion technique. There were, however, some discrepancies due to the viscoelastic behaviour of the respiratory system. Although slightly altered by these discrepancies, the multiple linear regression-elastance curves did fit the observed quasi-static pressure/volume characteristics for use in clinical practice. The multiple linear regression technique may prove to be clinically useful by continuous monitoring of respiratory system mechanics during mechanical ventilation.
K Muramatsu; K Yukitake; M Nakamura; I Matsumoto; Y Motohiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  17     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-08-08     Completed Date:  2001-12-18     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1158-66     Citation Subset:  IM    
Dept of Pediatrics, Fukuoka Tokushukai Medical Center, Kasuga City, Japan.
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MeSH Terms
Airway Resistance / physiology*
Infant, Newborn
Linear Models*
Lung Compliance / physiology*
Lung Volume Measurements*
Nonlinear Dynamics*
Respiration, Artificial / statistics & numerical data*
Respiratory Distress Syndrome, Newborn / physiopathology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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