Document Detail

Monitoring lupus anticoagulant-positive pregnancies with umbilical artery flow velocity waveforms.
MedLine Citation:
PMID:  3134628     Owner:  NLM     Status:  MEDLINE    
The presence of the "lupus anticoagulant" in maternal blood is associated with thrombosis in the placental vessels and a high rate of fetal loss. We followed six pregnancies in four mothers positive for lupus anticoagulant autoantibody with Doppler umbilical flow studies. The women were not treated with any drugs, and clinical management was guided by close fetal surveillance including umbilical flow studies. Umbilical artery flow velocity waveforms detect vascular abnormalities in the fetal umbilical placental circulation and were used as an early indicator of developing disease. All pregnancies produced live-born infants. These cases indicate the potential value of such studies in the management of this group at high risk of fetal loss.
B J Trudinger; G J Stewart; C M Cook; A Connelly; T Exner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  72     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-08-17     Completed Date:  1988-08-17     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  215-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Sydney at Westmead Hospital, NSW, Australia.
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MeSH Terms
Autoantibodies / analysis*
Blood Coagulation Disorders / blood,  immunology,  physiopathology*
Blood Coagulation Factors / blood,  immunology*
Blood Flow Velocity
Fetal Monitoring / methods*
Gestational Age
Infant, Newborn
Lupus Coagulation Inhibitor
Phospholipids / blood*
Pregnancy Complications, Hematologic / blood,  immunology,  physiopathology*
Pregnancy Outcome
Pregnancy Trimester, Second
Prenatal Care
Umbilical Arteries*
Vascular Resistance
Reg. No./Substance:
0/Autoantibodies; 0/Blood Coagulation Factors; 0/Lupus Coagulation Inhibitor; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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