| Monitoring lupus anticoagulant-positive pregnancies with umbilical artery flow velocity waveforms. | |
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MedLine Citation:
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PMID: 3134628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of the "lupus anticoagulant" in maternal blood is associated with thrombosis in the placental vessels and a high rate of fetal loss. We followed six pregnancies in four mothers positive for lupus anticoagulant autoantibody with Doppler umbilical flow studies. The women were not treated with any drugs, and clinical management was guided by close fetal surveillance including umbilical flow studies. Umbilical artery flow velocity waveforms detect vascular abnormalities in the fetal umbilical placental circulation and were used as an early indicator of developing disease. All pregnancies produced live-born infants. These cases indicate the potential value of such studies in the management of this group at high risk of fetal loss. |
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Authors:
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B J Trudinger; G J Stewart; C M Cook; A Connelly; T Exner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 72 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-08-17 Completed Date: 1988-08-17 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 215-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Sydney at Westmead Hospital, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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analysis* Blood Coagulation Disorders / blood, immunology, physiopathology* Blood Coagulation Factors / blood, immunology* Blood Flow Velocity Female Fetal Monitoring / methods* Gestational Age Humans Infant, Newborn Lupus Coagulation Inhibitor Phospholipids / blood* Pregnancy Pregnancy Complications, Hematologic / blood, immunology, physiopathology* Pregnancy Outcome Pregnancy Trimester, Second Prenatal Care Ultrasonography Umbilical Arteries* Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Blood Coagulation Factors; 0/Lupus Coagulation Inhibitor; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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