| Monitoring of liver glycogen synthesis in diabetic patients using carbon-13 MR spectroscopy. | |
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MedLine Citation:
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PMID: 19058940 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the relationship between liver glucose, glycogen, and plasma glucose in diabetic patients, in vivo liver carbon-13 magnetic resonance spectroscopy ((13)C MRS) with a clinical 3.0T MR system was performed. Subjects were healthy male volunteers (n=5) and male type-2 diabetic patients (n=5). Pre- and during oral glucose tolerance tests (OGTT), (13)C MR spectra without proton decoupling were acquired in a monitoring period of over 6h, and in total seven spectra were obtained from each subject. For OGTT, 75g of glucose, including 5g of [1-(13)C]glucose, was administered. The MR signals of liver [1-(13)C]glucose and glycogen were detected and their time-course changes were assessed in comparison with the plasma data obtained at screening. The correlations between the fasting plasma glucose level and liver glycogen/glucose rate (Spearman: rho=-0.68, p<0.05, n=10) and the fasting plasma glucose level and liver glycogen peak/fasting rate (Spearman: rho=-0.67, p<0.05, n=10) indicated that (13)C MRS can perform noninvasive measurement of glycogen storage/degradation ability in the liver individually and can assist in tailor-made therapy for diabetes. In conclusion, (13)C MRS has a potential to become a powerful tool in diagnosing diabetes multilaterally. |
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Authors:
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Moyoko Tomiyasu; Takayuki Obata; Yukio Nishi; Hiromitsu Nakamoto; Hiroi Nonaka; Yukihisa Takayama; Joonas Autio; Hiroo Ikehira; Iwao Kanno |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-05 |
Journal Detail:
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Title: European journal of radiology Volume: 73 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 300-4 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage, Chiba city, Chiba 263-8555, Japan. moyo@fml.nirs.go.jp <moyo@fml.nirs.go.jp> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Isotopes
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analysis,
diagnostic use Diabetes Mellitus, Type 2 / metabolism* Glucose / metabolism* Glycogen / biosynthesis* Humans Liver / metabolism* Magnetic Resonance Spectroscopy / methods* Male Metabolic Clearance Rate |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 50-99-7/Glucose; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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