| Monitoring of intraperitoneal administration of vancomycin in patients on continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 22264836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To validate a pharmacokinetic model of the treatments with intraperitoneal vancomycin applied to patients on continuous ambulatory peritoneal dialysis with bacterial peritonitis. METHODS: To carry out a prospective study divided in 2 cohorts: the first one including ten patients of 56±14 years and 65±5kg, and the second one with 10 patients (12 episodes of peritonitis) aged 52±13 years and 64±8kg. The treatment consists of administering and retaining for 6h in the peritoneal cavity a solution containing 2g of vancomycin and 1g of ceftazidime into 2 l of "dialysis solution". After the antibiotic administration, blood samples were obtained at 4, 6, 8, 10, 24, 48 and 168h in the first cohort and at 6 and 120h (C(VAN)(120)) in the second. The pharmacokinetic model was developed from the parameters obtained from the first cohort and was validated by the second cohort, calculating the mean error (ME) and the mean squared prediction error (MSPE) of the C(VAN)(120). RESULTS: Vancomycin serum concentrations fell from 39.63±7.62 mcg/ml at 4h to 8.55±2.87 mcg/ml at 168h for the first cohort, and from 37.65±6.84 mcg/ml at 6h to 10.82±2.66 mcg/ml at 120h (C(VAN)(120)) for the second cohort. The pharmacokinetics parameters were: C1=0.006 1/h/kg and Vd:=0.52 1/kg for the first cohort, and C1=0.006 1/h/kg and Vd:=0.53 1/kg for the second. The predictive ME and MSPE of the C(VAN)(120). were 0.59 mcg/ml ([EM*100/C(VAN)(120)=5.5%) and 10.38 mcg(2)/ml(2) ([MES*100/(C(VAN)(120))(2)]) respectively. CONCLUSION: The presented model shows an adequate exactitude and precision for the monitoring of intraperitoneal vancomycin in patients submitted to continuous ambulatory peritoneal dialysis with peritonitis. |
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Authors:
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B Montañés-Pauls; M Alós Almiñana; V G Casabó Alós; H García Pérez |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria Volume: - ISSN: 1130-6343 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440679 Medline TA: Farm Hosp Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 SEFH. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Farmacia, Centro Sociosanitario El Pinar, Castellón, España. |
Vernacular Title:
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Monitorización de la vacomicina en administración intraperitoneal en pacientes sometidos a diálisis peritoneal continua ambulatoria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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