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Monitoring genotoxic exposure in uranium miners.
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MedLine Citation:
PMID:  8319649     Owner:  NLM     Status:  MEDLINE    
Recent data from deep uranium mines in Czechoslovakia indicated that in addition to radon daughter products, miners are also exposed to chemical mutagens. Mycotoxins were identified as a possible source of mutagenicity present in the mines. Various methods of biomonitoring were used to examine three groups of miners from different uranium mines. Cytogenetic analysis of peripheral lymphocytes, unscheduled DNA synthesis (UDS) in lymphocytes, and lipid peroxidation (LPO) in both plasma and lymphocytes were studied on 66 exposed miners and 56 controls. Throat swabs were taken from 116 miners and 78 controls. Significantly increased numbers of aberrant cells were found in all groups of miners, as well as decreased UDS values in lymphocytes and increased LPO plasma levels in comparison to controls. Molds were detected in throat swabs from 27% of miners, and 58% of these molds were embryotoxic. Only 5% of the control samples contained molds and none of them was embryotoxic. The following mycotoxins were isolated from miners' throat swab samples: rugulosin, sterigmatocystin, mycophenolic acid, brevianamid A, citreoviridin, citrinin, penicilic acid, and secalonic acid. These data suggest that mycotoxins are a genotoxic factor affecting uranium miners.
R J Srám; B Binková; L Dobiás; P Rössner; J Topinka; D Veselá; D Veselý; J Stejskalová; H Bavorová; V Rericha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental health perspectives     Volume:  99     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-5     Citation Subset:  IM    
Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague.
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MeSH Terms
Chromosome Aberrations
DNA / biosynthesis
Environmental Monitoring
Lipid Peroxidation
Lung Neoplasms / etiology
Mycotoxins / adverse effects
Occupational Diseases / etiology
Occupational Exposure
Reg. No./Substance:
0/Mycotoxins; 7440-61-1/Uranium; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 3 Year: 1993
Volume: 99First Page: 303 Last Page: 305
ID: 1567033
PubMed Id: 8319649

Monitoring genotoxic exposure in uranium miners.
R J Sr?m
B Binkov?
L Dobi?s
P R?ssner
J Topinka
D Vesel?
D Vesel?
J Stejskalov?
H Bavorov?
V Rericha
Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Prague.

Article Categories:
  • Research Article

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