Document Detail


Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.
MedLine Citation:
PMID:  21951282     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.
Authors:
P Silva; J Barbosa; A V Nascimento; J Faria; R Reis; H Bousbaa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell proliferation     Volume:  44     ISSN:  1365-2184     ISO Abbreviation:  Cell Prolif.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105195     Medline TA:  Cell Prolif     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-400     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Health Sciences Research Center, Superior Institute of Health Sciences - North, CESPU, Gandra PRD, Portugal.
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