Document Detail


Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors.
MedLine Citation:
PMID:  15952896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because energy balance is important for survival, a system is required to monitor energy status and to make appropriate adjustments in energy intake and energy expenditure. In higher animals, a centrally located system has evolved to accomplish this task. When caloric intake exceeds expenditure, the surplus is channeled into energy storage pathways, primarily the synthesis of fatty acids, which are converted into fat and stored in adipose tissue. Thus, metabolic flux through the pathway of fatty acid synthesis, located in the lipogenic tissues, reflects the "energy status" of the animal. The enzymatic machinery of this pathway is also expressed in the brain, notably the hypothalamus. In the hypothalamus, intermediates in this pathway appear to serve as energy sensors that signal higher brain centers to produce appropriate responses, e.g., altered food intake and energy expenditure.
Authors:
Paul Dowell; Zhiyuan Hu; M Daniel Lane
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of biochemistry     Volume:  74     ISSN:  0066-4154     ISO Abbreviation:  Annu. Rev. Biochem.     Publication Date:  2005  
Date Detail:
Created Date:  2005-06-14     Completed Date:  2005-09-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2985150R     Medline TA:  Annu Rev Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-34     Citation Subset:  IM    
Affiliation:
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. dowellp@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Acyl Coenzyme A / metabolism
Animals
Eating
Energy Metabolism*
Fatty Acids / biosynthesis*
Hypothalamus / metabolism*
Malonyl Coenzyme A / metabolism
Mice
Models, Biological
Neurons / metabolism
Neuropeptides / metabolism
Signal Transduction
Chemical
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Fatty Acids; 0/Neuropeptides; 524-14-1/Malonyl Coenzyme A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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