| Monitoring the effect of anticoagulants on left atrial thrombi in patients with rheumatic heart disease: assessment with 111In-oxine-labelled platelet heart scintigraphy and transoesophageal echocardiography. | |
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MedLine Citation:
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PMID: 10994665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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111In-oxine-labelled platelet heart scintigraphy (In-plt) was used to evaluate the activity of left atrial thrombi detected by transoesophageal echocardiography (TEE) in 16 cases of rheumatic heart disease. The effect of anticoagulants on the therapeutic intervention of these patients was evaluated by In-plt and TEE. In-plt was performed in all patients in serial pre- and post-anticoagulant therapy studies with anterior, 45 degrees left anterior oblique and left lateral views taken daily from the second to sixth day after injection of labelled platelets. After discontinuing anticoagulants for at least 1 week, only nine cases of left atrial thrombi were detected among the 16 cases by initial In-plt. After anticoagulants were again used for at least 3 weeks, all nine positive cases became negative on repeat In-plt. These results suggest that the diagnostic sensitivity of In-plt is lower than that of TEE. However, In-plt is more suitable and useful for evaluating the activity of left atrial thrombi after antithrombotic agent therapy and for monitoring the effect of anticoagulant therapy on left atrial thrombi in patients with rheumatic heart disease. |
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Authors:
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S S Sun; J F Hsieh; S C Tsai; Y J Ho; J K Lee; C H Kao |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 21 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2001-02-02 Completed Date: 2001-02-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 627-30 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, China Medical College Hospital, Taichung, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticoagulants / pharmacology* Atrial Function, Left Blood Platelets / radionuclide imaging Coronary Thrombosis / drug therapy*, radionuclide imaging*, ultrasonography Echocardiography, Transesophageal Female Heart Atria / radionuclide imaging, ultrasonography Humans Male Middle Aged Organometallic Compounds / diagnostic use* Oxyquinoline / analogs & derivatives*, diagnostic use Radiopharmaceuticals / diagnostic use* Rheumatic Heart Disease / radionuclide imaging*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Organometallic Compounds; 0/Radiopharmaceuticals; 14514-42-2/indium oxine; 148-24-3/Oxyquinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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