Document Detail

Monitoring the effect of anticoagulants on left atrial thrombi in patients with rheumatic heart disease: assessment with 111In-oxine-labelled platelet heart scintigraphy and transoesophageal echocardiography.
MedLine Citation:
PMID:  10994665     Owner:  NLM     Status:  MEDLINE    
111In-oxine-labelled platelet heart scintigraphy (In-plt) was used to evaluate the activity of left atrial thrombi detected by transoesophageal echocardiography (TEE) in 16 cases of rheumatic heart disease. The effect of anticoagulants on the therapeutic intervention of these patients was evaluated by In-plt and TEE. In-plt was performed in all patients in serial pre- and post-anticoagulant therapy studies with anterior, 45 degrees left anterior oblique and left lateral views taken daily from the second to sixth day after injection of labelled platelets. After discontinuing anticoagulants for at least 1 week, only nine cases of left atrial thrombi were detected among the 16 cases by initial In-plt. After anticoagulants were again used for at least 3 weeks, all nine positive cases became negative on repeat In-plt. These results suggest that the diagnostic sensitivity of In-plt is lower than that of TEE. However, In-plt is more suitable and useful for evaluating the activity of left atrial thrombi after antithrombotic agent therapy and for monitoring the effect of anticoagulant therapy on left atrial thrombi in patients with rheumatic heart disease.
S S Sun; J F Hsieh; S C Tsai; Y J Ho; J K Lee; C H Kao
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  21     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  627-30     Citation Subset:  IM    
Department of Nuclear Medicine, China Medical College Hospital, Taichung, Taiwan, Republic of China.
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MeSH Terms
Anticoagulants / pharmacology*
Atrial Function, Left
Blood Platelets / radionuclide imaging
Coronary Thrombosis / drug therapy*,  radionuclide imaging*,  ultrasonography
Echocardiography, Transesophageal
Heart Atria / radionuclide imaging,  ultrasonography
Middle Aged
Organometallic Compounds / diagnostic use*
Oxyquinoline / analogs & derivatives*,  diagnostic use
Radiopharmaceuticals / diagnostic use*
Rheumatic Heart Disease / radionuclide imaging*,  ultrasonography
Reg. No./Substance:
0/Anticoagulants; 0/Organometallic Compounds; 0/Radiopharmaceuticals; 14514-42-2/indium oxine; 148-24-3/Oxyquinoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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