Document Detail

Monitoring dopamine release from single living vesicles with nanoelectrodes.
MedLine Citation:
PMID:  15969544     Owner:  NLM     Status:  MEDLINE    
Carbon fiber nanoelectrodes (tip diameter = ca. 100 nm) have been first used to monitor real-time dopamine release from single living vesicles of single rat pheochromocytoma (PC12) cells. The experiments show that active and inactive release sites exist on the surface of cells, and the spatial distributions have been differentiated even in the same active release zone. It is first demonstrated that multiple vesicles can sequentially release dopamine at the same site of the cell surface, which possibly plays the main role in the dopamine release from PC12 cells.
Wen-Zhan Wu; Wei-Hua Huang; Wei Wang; Zong-Li Wang; Jie-Ke Cheng; Tao Xu; Rong-Ying Zhang; Yu Chen; Jie Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  127     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-22     Completed Date:  2005-10-26     Revised Date:  2008-01-17    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8914-5     Citation Subset:  IM    
Department of Chemistry, Wuhan University, Wuhan 430072, China.
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MeSH Terms
Action Potentials / physiology
Carbon / chemistry
Dopamine / chemistry,  metabolism*,  secretion
Exocytosis / physiology
Neurotransmitter Agents / chemistry
PC12 Cells
Reg. No./Substance:
0/Neurotransmitter Agents; 0/carbon fiber; 7440-44-0/Carbon

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