Document Detail

Monitoring the conjunctiva for carbon dioxide and oxygen tensions and pH during cardiopulmonary bypass.
MedLine Citation:
PMID:  21449229     Owner:  NLM     Status:  In-Process    
The purpose of this study was to measure, for the first time, multiple physiologic parameters of perfusion (pH, PCO2, PO2, and temperature) from the conjunctiva of adult patients during cardiopulmonary bypass while undergoing cardiothoracic surgery. Ten patients who underwent either intracardiac valve repair, atrial septal defect repair, or coronary artery bypass graft surgery had placement of a sensor which directly measured pH, PCO2, PO2, and temperature from the conjunctiva. Data were stratified into seven phases (0-5 minutes prior to bypass; 0-5, 6-10, and 11-15 minutes after initiation of bypass; 0-5 minutes prior to conclusion of bypass; and 0-5 and 6-10 minutes after bypass) and analyzed using a mixed model analysis.The change in conjunctival pH over the course of measurement was not statistically significant (p = .56). The PCO2 level followed a quadratic pattern, decreasing from a mean pre-bypass level of 37.7 mmHg at baseline prior to the initiation of cardiopulmonary bypass to a nadir of 33.2 mmHg, then increasing to a high of 39.4 mmHg at 6-10 minutes post bypass (p < .01). The PO2 declined from a mean pre-bypass level of 79.5 mmHg to 31.3 mmHg by 6-10 minutes post bypass and even post-bypass, it never returned to baseline values (p < .01). Temperature followed a pattern similar to PCO2 by returning to baseline levels as the patient was re-warmed following bypass (p < .01). There was no evidence of any eye injury or inflammation following the removal of the sensor. In the subjects studied, the conjunctival sensor yielded reproducible measurements during the various phases of cardiopulmonary bypass without ocular injury. Further study is necessary to determine the role of conjunctival measurements in critical settings.
Irwin K Weiss; Sherwin J Isenberg; David L McArthur; Madeline Del Signore; John S McDonald
Related Documents :
3379099 - Bioprosthetic valve excision without replacement in the tricuspid position in a patient...
12220069 - Dextrocardia: technical aspects of reoperative aortic and tricuspid valve replacement.
154599 - Caplike double-horned double-outlet right ventricle. report of two cases.
2808279 - Estimation of pulmonary artery pressure by colour guided continuous wave doppler in cas...
15070269 - Pulmonary atresia or critical pulmonary stenosis with intact interventricular septum di...
3899649 - Diagnosis of tricuspid regurgitation. sensitivity of doppler ultrasound compared with c...
2680739 - Radiological evaluation of hepatic artery aneurysms.
8516449 - Preoperative diagnosis of meckel's diverticulum in a 62-year-old man: utility of an ang...
24236229 - Automated anatomical labeling of the cerebral arteries using belief propagation.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of extra-corporeal technology     Volume:  43     ISSN:  0022-1058     ISO Abbreviation:  J Extra Corpor Technol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267637     Medline TA:  J Extra Corpor Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  T    
Department of Pediatrics, David Geffen School of Medicine at UCLA, Mattel Children's Hospital UCLA, Los Angeles, California 90095-1752, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Heparin-induced thrombocytopenia and extracorporeal membrane oxygenation: a case report and review o...
Next Document:  Thrombography reveals thrombin generation potential continues to deteriorate following cardiopulmona...