| Monitoring clonal growth in the developing ventricle. | |
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MedLine Citation:
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PMID: 19184177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the etiology of congenital heart defects depends on a detailed knowledge of the morphogenetic events underlying cardiac development. Deciphering the developmental processes and cell behaviors resulting in the formation of a four-chambered heart requires techniques by which the destiny of individual cells can be traced during development. Ideally, such approaches provide information on progenitor cells and growth properties of clonally related myocytes. In the avian system, clonal analysis based on the use of replication-defective retroviral labeling led to a model for growth of the ventricular wall from polyclonal transmural cones of myocardial cells. In the mouse, the nlaacZ retrospective clonal analysis system has proved to be a powerful technique for studying different aspects of cardiac morphogenesis. Morphologic and histologic analyses of clonally related myocytes at early stages of development have provided genetic evidence for the formation of the heart tube from two cell lineages. Additional aspects of cardiac morphogenesis, including formation of the interventricular septum and myocardial outflow tract, and more recently, the origin of the ventricular conduction system, have been studied using this system. This brief review discusses how the nlaacZ system has provided new insights into the divergent properties of clonally related cells in these different regions of the developing heart. |
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Authors:
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Lucile Miquerol; Robert G Kelly |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-28 |
Journal Detail:
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Title: Pediatric cardiology Volume: 30 ISSN: 1432-1971 ISO Abbreviation: Pediatr Cardiol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-08 Completed Date: 2009-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 603-8 Citation Subset: IM |
Affiliation:
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Developmental Biology Institute of Marseilles-Luminy, Inserm Avenir Group, UMR 6216 CNRS-Université de Méditerranée, Campus de Luminy, Case 907, Marseille Cedex 9 13288, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clone Cells / physiology* Heart Conduction System / cytology, embryology* Heart Septum / cytology, embryology* Heart Ventricles / cytology, embryology* Mice beta-Galactosidase / genetics |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.23/beta-Galactosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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