Document Detail


Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor.
MedLine Citation:
PMID:  22899095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: A genetically encoded fluorescent BAS was developed that allows intracellular imaging of bile acid homeostasis in single living cells in real time.
Authors:
Lieke M van der Velden; Misha V Golynskiy; Ingrid T G W Bijsmans; Saskia W C van Mil; Leo W J Klomp; Maarten Merkx; Stan F J van de Graaf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-04-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  740-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / metabolism*
Biosensing Techniques / methods
Carrier Proteins
Cell Nucleus / metabolism
Cytoplasm / metabolism
Fluorescence Resonance Energy Transfer / methods*
Fluorescent Dyes / diagnostic use
Humans
Membrane Glycoproteins
Membrane Transport Proteins / biosynthesis
Organic Anion Transporters, Sodium-Dependent / genetics,  metabolism*
Receptors, Cytoplasmic and Nuclear / metabolism
Symporters / genetics,  metabolism*
Zebrafish
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Carrier Proteins; 0/Fluorescent Dyes; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Organic Anion Transporters, Sodium-Dependent; 0/Receptors, Cytoplasmic and Nuclear; 0/Symporters; 0/bile acid binding proteins; 0/farnesoid X-activated receptor; 0/organic solute transporter alpha, human; 145420-23-1/sodium-bile acid cotransporter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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