| Monitoring angiogenesis using a human compatible calibration for broadband near-infrared spectroscopy. | |
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MedLine Citation:
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PMID: 23314579 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT. Angiogenesis is a hallmark of many conditions, including cancer, stroke, vascular disease, diabetes, and high-altitude exposure. We have previously shown that one can study angiogenesis in animal models by using total hemoglobin (tHb) as a marker of cerebral blood volume (CBV), measured using broadband near-infrared spectroscopy (bNIRS). However, the method was not suitable for patients as global anoxia was used for the calibration. Here we determine if angiogenesis could be detected using a calibration method that could be applied to patients. CBV, as a marker of angiogenesis, is quantified in a rat cortex before and after hypoxia acclimation. Rats are acclimated at 370-mmHg pressure for three weeks, while rats in the control group are housed under the same conditions, but under normal pressure. CBV increased in each animal in the acclimation group. The mean CBV (%volume/volume) is 3.49%±0.43% (mean±SD) before acclimation for the experimental group, and 4.76%±0.29% after acclimation. The CBV for the control group is 3.28%±0.75%, and 3.09%±0.48% for the two measurements. This demonstrates that angiogenesis can be monitored noninvasively over time using a bNIRS system with a calibration method that is compatible with human use and less stressful for studies using animals. |
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Authors:
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Runze Yang; Qiong Zhang; Ying Wu; Jeff F Dunn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical optics Volume: 18 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 16011 Citation Subset: IM |
Affiliation:
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University of Calgary, Department of Radiology, Calgary, Alberta, CanadabUniversity of Calgary, Hotchkiss Brain Institute, Calgary, Alberta, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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