Document Detail


Monitoring of acute myeloid leukemia by flow cytometry.
MedLine Citation:
PMID:  12895393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monitoring of minimal residual disease (MRD) becomes increasingly important in the risk-adapted management of patients with acute myeloid leukemia (AML). In selected patients with AML, multiparameter flow cytometry has shown accuracy and sensitivity in the quantification of MRD levels with independent prognostic impact. The applicability of this approach is superior to that of other methods such as quantitative polymerase chain reaction: Up to 80% of all patients can be monitored by flow cytometry. Nonetheless, significant technical advances are anticipated to extend the applicability of flow cytometry to 100% and to improve its sensitivity. Large clinical trials will determine the role of immunologic monitoring in the prognostic stratification of patients with AML.
Authors:
Wolfgang Kern; Susanne Schnittger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current oncology reports     Volume:  5     ISSN:  1523-3790     ISO Abbreviation:  Curr Oncol Rep     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-04     Completed Date:  2004-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888967     Medline TA:  Curr Oncol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Affiliation:
Laboratory for Leukemia Diagnostics, Ludwig-Maximilians-University, University Hospital Grosshadern, Department of Internal Medicine III, 81366 Munich, Germany. wolfgang.kern@med3.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Antigens, CD45
Flow Cytometry*
Immunophenotyping
Leukemia, Myelomonocytic, Acute / immunology*,  therapy
Monitoring, Immunologic*
Neoplasm, Residual
Polymerase Chain Reaction
Prognosis
Recurrence
Sensitivity and Specificity
Chemical
Reg. No./Substance:
EC 3.1.3.48/Antigens, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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