Document Detail

Monitoring activity of fibrinolytic agents. A therapeutic challenge.
MedLine Citation:
PMID:  6232847     Owner:  NLM     Status:  MEDLINE    
The recognition that thrombolytic therapy may be beneficial for coronary thrombolysis has led to an increased use of plasminogen activators in critically ill patients, sometimes with inadequate monitoring. This review delineates the components of the fibrinolytic system, describes mechanisms of fibrinolysis, and presents practical guidelines for monitoring the use of activators of the system.
K E Shafer; S A Santoro; B E Sobel; A S Jaffe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  76     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-06-05     Completed Date:  1984-06-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  879-86     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Coagulation Disorders / drug therapy
Drug Administration Schedule
Fibrin Fibrinogen Degradation Products / pharmacology
Fibrinolysin / antagonists & inhibitors,  physiology
Fibrinolysis / drug effects
Fibrinolytic Agents* / administration & dosage,  therapeutic use
Partial Thromboplastin Time
Plasminogen Activators / physiology
Prothrombin Time
Streptokinase / pharmacology
Thrombin Time
Urokinase-Type Plasminogen Activator / pharmacology
Grant Support
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Fibrinolytic Agents; EC 3.4.-/Streptokinase; EC 3.4.21.-/Plasminogen Activators; EC; EC Plasminogen Activator

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