| Monitoring fetal electrocortical activity during labour for predicting worsening acidemia: a prospective study in the ovine fetus near term. | |
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MedLine Citation:
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PMID: 21789218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Severe fetal acidemia during labour with arterial pH below 7.00 is associated with increased risk of hypoxic-ischemic brain injury. Electronic fetal heart rate (FHR) monitoring, the mainstay of intrapartum surveillance, has poor specificity for detecting fetal acidemia. We studied brain electrical activity measured with electrocorticogram (ECOG) in the near term ovine fetus subjected to repetitive umbilical cord occlusions (UCO) inducing FHR decelerations, as might be seen in human labour, to delineate the time-course for ECOG changes with worsening acidemia and thereby assess the potential clinical utility of fetal ECOG. METHODOLOGY/PRINCIPAL FINDINGS: Ten chronically catheterized fetal sheep were studied through a series of mild, moderate and severe UCO until the arterial pH was below 7.00. At a pH of 7.24 ± 0.04, 52 ± 13 min prior to the pH dropping <7.00, spectral edge frequency (SEF) increased to 23 ± 2 Hz from 3 ± 1 Hz during each FHR deceleration (p<0.001) and was correlated to decreases in FHR and in fetal arterial blood pressure during each FHR deceleration (p<0.001). CONCLUSIONS/SIGNIFICANCE: The UCO-related changes in ECOG occurred in advance of the pH decreasing below 7.00. These ECOG changes may be a protective mechanism suppressing non-essential energy needs when oxygen supply to the fetal brain is decreased acutely. By detecting such "adaptive brain shutdown," the need for delivery in high risk pregnant patients may be more accurately predicted than with FHR monitoring alone. Therefore, monitoring fetal electroencephalogram (EEG, the human equivalent of ECOG) during human labour may be a useful adjunct to FHR monitoring. |
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Authors:
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Martin G Frasch; Ashley E Keen; Robert Gagnon; Michael G Ross; Bryan S Richardson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-07-15 |
Journal Detail:
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Title: PloS one Volume: 6 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-26 Completed Date: 2011-11-22 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States |
Other Details:
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Languages: eng Pagination: e22100 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada. mg.frasch@umontreal.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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diagnosis*,
embryology*,
physiopathology Animals Cerebral Cortex / physiopathology* Electroencephalography Female Fetal Monitoring / methods* Fetal Movement / physiology* Fetus / physiopathology* Gases / blood Heart / physiopathology Heart Rate, Fetal / physiology Humans Hydrogen-Ion Concentration Labor, Obstetric / physiology* Male Oxygen Pregnancy Sheep, Domestic |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Gases; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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