Document Detail


Monitoring Cardiac Function During Idebenone Therapy in Friedreich's Ataxia.
MedLine Citation:
PMID:  25483949     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Friedreich's ataxia (FA) is associated with progressive cardiac hypertrophy resulting from a genetic abnormality in the frataxin gene. Cardiac involvement is the most common cause of death (59%) in FA patients. Cardiac related death occurs at a significantly younger age than non-cardiac related death. Idebenone is a short-chain quinone analogue with a potent free-radical scavenger action. This drug has the potential to preserve and even improve mitochondrial function.Studies on Idebenone treatment showed rather conflicting results on FA cardiomyopathy. The present article reviews the clinical features of FA cardiomyopathy, imaging techniques used to diagnose, follow and monitor therapy which aimed to revert FA cardiomyopathy.
Authors:
Di Salvo Giovanni; Pergola Valeria; Fadel Bahaa; Al Fayyadh Majid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  21     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2014  
Date Detail:
Created Date:  2014-12-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  479-83     Citation Subset:  IM    
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