Document Detail


Monitoring 6 weeks of progressive endurance training with plasma glutamine.
MedLine Citation:
PMID:  17024635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distinction between positive and negative training adaptation is an important prerequisite in the identification of any marker for monitoring training in athletes. To investigate the glutamine responses to progressive endurance training, twenty healthy males were randomly assigned to a training group or a non-exercising control group. The training group performed a progressive (3 to 6 x 90 minute sessions per week at 70 % V.O (2max)) six-week endurance training programme on a cycle ergometer, while the control group did not participate in any exercise during this period. Performance assessments (V.O (2max) and time to exhaustion) and resting blood samples (for haemoglobin concentration, haematocrit, cortisol, ferritin, creatine kinase, glutamine, uric acid and urea analysis) were obtained prior to the commencement of training (Pre) and at the end of week 2, week 4 and week 6. The training group showed significant improvements in time to exhaustion (p < 0.01), and V.O (2max) (p < 0.05) at all time points (except week 2 for V.O (2max)), while the control group performance measures did not change. In the training group, haemoglobin concentration and haematocrit were significantly lower (p < 0.01) than pretraining values at week 2 and 4, as percentage changes in plasma volume indicated a significant (p < 0.01) haemodilution (+ 6 - 9 %) was present at week 2, 4 and 6. No changes were seen in the control group. In the training group, plasma glutamine (week 2, 4 and 6), creatine kinase (week 2 and 4), uric acid (week 2 and 4) and urea (week 2 and 4) all increased significantly from pretraining levels. No changes in cortisol or ferritin were found in the training group and no changes in any blood variables were present in the control group. Plasma glutamine was the only blood variable to remain significantly above pretraining (966 +/- 32 micromol . 1 (-1)) levels at week 6 (1176 +/- 24 micromol . 1 (-1); p < 0.05) The elevation seen here in glutamine levels, after 6 weeks of progressive endurance training, is in contrast to previous reports of decreased glutamine concentrations in overtrained athletes. In conclusion, 6 weeks of progressive endurance training steadily increased plasma glutamine levels, which may prove useful in the monitoring of training responses.
Authors:
S Kargotich; D Keast; C Goodman; C I Bhagat; D J L Joske; B Dawson; A R Morton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-10-06
Journal Detail:
Title:  International journal of sports medicine     Volume:  28     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
Affiliation:
School of Microbiology, The University of Western Australia, QE II Medical Centre, Nedlands, WA, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Creatine Kinase / blood
Exercise Test
Glutamine / blood*
Hematocrit
Hemodilution
Hemoglobins / analysis
Humans
Male
Oxygen Consumption / physiology
Physical Education and Training / methods*
Physical Endurance / physiology*
Plasma Volume / physiology
Uric Acid / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobins; 56-85-9/Glutamine; 69-93-2/Uric Acid; EC 2.7.3.2/Creatine Kinase

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